Pregnenolone is often referred to as the grandparent precursor to steroid hormones in mammals. Pregnenolone is synthesized from cholesterol in the mitochondria of adrenal glands. Pregnenolone is also made to lesser extent in the brain, liver, skin, testes, and ovaries.
Once synthesized, pregnenolone is released from the mitochondria into the cytosol where it can be converted to DHEA (dehydroepiandrosterone) or to progesterone. DHEA serves as a precursor through androstenedione as the intermediate compound. Progesterone is the precursor to cortisol, aldosterone, androstenedione, estrogen, and testosterone.
Pregnenolone may also be secreted directly into the blood where it circulates primarily as the sulfated form. Pregnenolone has many actions of its own not attributable to its conversion to progesterone or to DHEA. Recent studies show that pregnenolone is important for the function of brain, nervous tissue, liver, pancreas, reproductive tissues, pituitary, and skin. Pregnenolone is found in higher concentrations in the central nervous system compared to the peripheral tissues which may reflect its importance in brain function.
As with many hormones, pregnenolone production declines with age. It is estimated that pregnenolone production is about 60% less at age of 75 than at age 35. Pregnenolone levels may also decline under
various conditions of physiological stress, such as acute and chronic infections and trauma.
Each 25 mg. sublingual tablet contains: Pregnenolone……………………………..5 mg.